Chapter 14. Crosstalk Between Cell–Cell and Cell–Matrix Adhesion

  1. Prof. Dr. Susan E. LaFlamme1 and
  2. Prof. Andrew P. Kowalczyk2
  1. C. Michael DiPersio

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch14

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

How to Cite

DiPersio, C. M. (2008) Crosstalk Between Cell–Cell and Cell–Matrix Adhesion, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch14

Editor Information

  1. 1

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 2

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092

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Keywords:

  • cell junctions;
  • cell–matrix adhesion;
  • cell–cell adhesion;
  • crosstalk;
  • integrins;
  • cadherins;
  • integrin–cadherin crosstalk mechanisms;
  • extracellular proteolysis;
  • intracellular signal transduction pathways

Summary

This chapter contains sections titled:

  • Introduction

    • Coordinate Regulation of Cell–Cell and Cell–Matrix Adhesion

    • Crosstalk Between Integrins and Cadherins

  • Mechanisms of Integrin–Cadherin Crosstalk

    • Extracellular Proteolysis

    • Cross-Regulation of Gene Expression

    • Changes in Intracellular Force Generation

    • Integrin–Cadherin Associations at Sites of Cell Adhesion

    • Intracellular Signal Transduction Pathways

      • FAK: An Integrin Effector that Signals to Cadherins

      • Fer: A Tyrosine Kinase that Translocates between Cadherins and Integrins

      • Rap1: A Central Regulator of Integrin–Cadherin Crosstalk Pathways?

      • The Epidermis as a Model for Investigating Cadherin–Integrin Crosstalk

  • Future Prospects

  • Acknowledgments

  • References