Chapter 2. Integrin Signaling Through Focal Adhesion Kinase

  1. Prof. Dr. Susan E. LaFlamme3 and
  2. Prof. Andrew P. Kowalczyk4
  1. Youngdong Yoo1,2 and
  2. Jun-Lin Guan1,2

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch2

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

How to Cite

Yoo, Y. and Guan, J.-L. (2008) Integrin Signaling Through Focal Adhesion Kinase, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch2

Editor Information

  1. 3

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 4

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. 1

    University of Michigan Medical School, Department of Internal Medicine, Division of Molecular Medicine and Genetics, Ann Arbor, MI 48109-2200, USA

  2. 2

    Department of Cell and Developmental Biology, Ann Arbor, MI 48109-2200, USA

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092

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Keywords:

  • cell junctions;
  • cell–matrix junctions;
  • integrin signalling;
  • focal adhesion kinase (FAK);
  • structure of FAK;
  • FAK activity regulation;
  • regulation of cellular functions;
  • FAK signaling pathways

Summary

This chapter contains sections titled:

  • Introduction

  • Structure of FAK

  • Regulation of FAK Activity

    • Activation of FAK

    • Inhibition of FAK Activity

  • Regulation of Cellular Functions by FAK Signaling Pathways

    • Cell Adhesion and Spreading

    • Cell Migration and Invasion

    • Cell Survival and Proliferation

  • Recent Analysis of FAK Functions In Vivo

  • Conclusions

  • Acknowledgment

  • References