Chapter 4. Adhesion Dynamics in Motile Cells

  1. Prof. Dr. Susan E. LaFlamme4 and
  2. Prof. Andrew P. Kowalczyk5
  1. Christa L. Cortesio1,
  2. Keefe T. Chan2 and
  3. Anna Huttenlocher3

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch4

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

How to Cite

Cortesio, C. L., Chan, K. T. and Huttenlocher, A. (2008) Adhesion Dynamics in Motile Cells, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch4

Editor Information

  1. 4

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 5

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. 1

    University of Wisconsin-Madison, Department of Biomolecular Chemistry, 1550 Linden Drive, Madison, WI 53706, USA

  2. 2

    University of Wisconsin-Madison, Department of Molecular and Cellular Pharmacology, 1550 Linden Drive, Madison, WI 53706, USA

  3. 3

    University of Wisconsin-Medison, 1550 Linden Drive, Madison, WI 53706, USA

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092

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Keywords:

  • cell junctions;
  • cell–matrix junctions;
  • adhesion dynamics;
  • motile cells;
  • focal adhesion dynamics;
  • podosome dynamics;
  • invadopodia dynamics

Summary

This chapter contains sections titled:

  • Introduction

  • Focal Adhesion Dynamics

    • Focal Adhesion Composition

    • Mechanisms of Focal Adhesion Assembly

      • Rho GTPases

      • Talin and Phosphoinositides

    • Mechanisms of Focal Adhesion Disassembly

      • Calpain

      • Tyrosine Phosphorylation and Contractile Machinery

  • Podosome and Invadopodia Dynamics

    • Podosome and Invadopodia Architecture

    • Molecular Mechanisms of PTA Assembly

      • Actin Regulatory Proteins

      • Rho GTPases

      • Signaling Molecules

    • Molecular Mechanisms of PTA Disassembly

  • Summary

  • Acknowledgments

  • References