Chapter 6. Hemidesmosomes and their Components: Adhesion versus Signaling in Health and Disease

  1. Prof. Dr. Susan E. LaFlamme2 and
  2. Prof. Andrew P. Kowalczyk3
  1. Kristina Kligys,
  2. Kevin Hamill and
  3. Jonathan C. R. Jones

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch6

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

How to Cite

Kligys, K., Hamill, K. and Jones, J. C. R. (2008) Hemidesmosomes and their Components: Adhesion versus Signaling in Health and Disease, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch6

Editor Information

  1. 2

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 3

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. Northwestern University, Feinberg School of Medicine, Department of Cell and Molecular Biology, 303 E. Chicago Avenue, Chicago, IL 60611, USA

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092

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Keywords:

  • cell junctions;
  • cell–matrix junctions;
  • hemidesmosomes;
  • structural components;
  • laminin-332;
  • hemidesmosome assembly;
  • hemidesmosome disassembly;
  • hemidesmosomes and disease;
  • α6β4 integrin expression;
  • laminin-332 expression;
  • cancer;
  • signaling by α6β4 integrin

Summary

This chapter contains sections titled:

  • Introduction

  • The Structural Components of the Hemidesmosome

    • The Plaque Proteins

      • Plectin

      • BP230

    • Membrane Elements

      • α6β4 Integrin

      • BP180

      • CD151

  • Laminin-332

  • Hemidesmosome Assembly and Disassembly

  • Hemidesmosomes and Disease

    • Inherited Skin Diseases Involving Hemidesmosome Proteins

      • Disease Involving α6β4 Integrin

      • Disease Involving Plectin

      • Disease Involving BP180

      • Disease Involving CD151

      • Disease Involving Laminin-332

    • Autoimmune Diseases Associated with Hemidesmosomes

      • BP and Related Diseases

      • Cicatricial Pemphigoid

      • Autoimmune Diseases Involving α6β4 Integrin

  • α6β4 Integrin and Laminin-332 Expression in Cancer

  • Signaling by the α6β4 Integrin in Pathological States and Wound Healing

  • Laminin-332, α6β4 Integrin and Migration

  • Conclusions

  • References