Chapter 7. Cell Matrix Adhesion in Three Dimensions
- Prof. Dr. Susan E. LaFlamme2,
- Prof. Andrew P. Kowalczyk3
Published Online: 11 APR 2008
DOI: 10.1002/9783527622092.ch7
Copyright © 2008 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Cell Junctions: Adhesion, Development, and Disease
Additional Information
How to Cite
Keely, P. J. (2008) Cell Matrix Adhesion in Three Dimensions, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch7
Editor Information
- 2
Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA
- 3
Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA
Publication History
- Published Online: 11 APR 2008
- Published Print: 26 MAR 2008
ISBN Information
Print ISBN: 9783527318827
Online ISBN: 9783527622092
- Summary
- Chapter
- References
Keywords:
- cell junctions;
- cell–matrix junctions;
- cell matrix adhesion;
- three dimensions;
- model 3D matrices;
- cell behaviour;
- adhesive structures;
- difference between 3D and 2D matrices;
- compliancy;
- elastic modulus;
- cellular response to ECMs
Summary
This chapter contains sections titled:
Introduction
Model 3D Matrices for Investigations of Cell Behavior
Matrigel/Reconstituted Basement Membrane (rBM)
Collagen Gels
Fibrin Gels
Cell-Derived Fibronectin-Based Matrices
Engineered 3D Matrices and Microfluidic Chambers
Cell Behavior and Adhesive Structures Differ between 3D and 2D Matrices
“Compliancy” or Elastic Modulus Determines Cellular Response to ECMs
Cellular Contractility and the Response to Matrix Compliance
Rho Regulates the Cytoskeleton and Contractility
Rho/ROCK, Contractility, and Focal Adhesion Formation
Focal Adhesions as Transducers of Biophysical Signals
A Model for Cellular Response to 3D Matrices Varying in Compliance
Acknowledgments
References