Chapter 9. Signaling To and Through The Endothelial Adherens Junction

  1. Prof. Dr. Susan E. LaFlamme2 and
  2. Prof. Andrew P. Kowalczyk3
  1. Deana M. Ferreri and
  2. Peter A. Vincent

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch9

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

How to Cite

Ferreri, D. M. and Vincent, P. A. (2008) Signaling To and Through The Endothelial Adherens Junction, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch9

Editor Information

  1. 2

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 3

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. Albany Medical College, Center for Cardiovascular Sciences, 47 New Scotland Avenue, Albany, NY 12208, USA

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092

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Keywords:

  • cell junctions;
  • signalling;
  • endothelial adherence junction;
  • cadherins;
  • phosphorylation;
  • junction assembly/disassembly;
  • small GTPases;
  • junction assembly

Summary

This chapter contains sections titled:

  • Introduction

  • Cadherins

    • VE-Cadherin Extracellular Domain

    • Interaction of Cadherin Cytoplasmic Domain and Catenins

      • VE-Cadherin Juxtamembrane Region and p120

      • VE-Cadherin Catenin Binding Domain

  • Phosphorylation and Junction Assembly/Disassembly

    • Tyrosine Phosphorylation of Endothelial AJ Proteins

    • Serine/Threonine Phosphorylation of Endothelial AJ Proteins

  • Small GTPases and Junction Assembly

    • Rho GTPases

    • Rap1 GTPase

  • Conclusions

  • References