Chapter 2. A Meta-Analysis of Large-Scale Gene Expression Studies of the Injured PNS: Toward the Genetic Networks That Govern Successful Regeneration

  1. Prof. Dr. Hans Werner Müller
  1. Floor J. Stam1,
  2. Matthew R. J. Mason2,
  3. August B. Smit1 and
  4. Joost Verhaagen2

Published Online: 16 JUN 2008

DOI: 10.1002/9783527622467.ch2

Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology

Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology

How to Cite

Stam, F. J., Mason, M. R. J., Smit, A. B. and Verhaagen, J. (2008) A Meta-Analysis of Large-Scale Gene Expression Studies of the Injured PNS: Toward the Genetic Networks That Govern Successful Regeneration, in Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology (ed H. W. Müller), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622467.ch2

Editor Information

  1. Heinrich-Heine University, Department of Neurology and Biomedical Research Center, Molecular Neurobiology Laboratory, Moorenstrasse 5, 40225 Düsseldorf, Germany

Author Information

  1. 1

    Vrije Universiteit, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, 1105 AZ Amsterdam, The Netherlands

  2. 2

    Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

Publication History

  1. Published Online: 16 JUN 2008
  2. Published Print: 20 FEB 2008

ISBN Information

Print ISBN: 9783527317073

Online ISBN: 9783527622467

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Keywords:

  • neural degeneration;
  • neural repair;
  • large-scale gene expression studies;
  • injured peripheral nervous system (PNS);
  • lesion models;
  • cellular events;
  • large-scale screening efforts;
  • novel regeneration-associated genes;
  • molecular biology;
  • regenerative neurite outgrowth

Summary

This chapter contains sections titled:

  • Introduction

  • Lesion Models in the Peripheral Nervous System

  • Cellular Events After Injury

  • Large-Scale Screening Efforts to Find Novel Regeneration-Associated Genes

  • Developing New Insights into the Molecular Biology of Regenerative Neurite Outgrowth: From Single Gene to Genetic Networks

  • References