Chapter 5. The Role of Gene Expression Dependent Molecular Pathways in Axon Plasticity and Neuron Repair Following Acute CNS Injury

  1. Prof. Dr. Hans Werner Müller
  1. Simone Di Giovanni

Published Online: 16 JUN 2008

DOI: 10.1002/9783527622467.ch5

Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology

Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology

How to Cite

Di Giovanni, S. (2008) The Role of Gene Expression Dependent Molecular Pathways in Axon Plasticity and Neuron Repair Following Acute CNS Injury, in Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology (ed H. W. Müller), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622467.ch5

Editor Information

  1. Heinrich-Heine University, Department of Neurology and Biomedical Research Center, Molecular Neurobiology Laboratory, Moorenstrasse 5, 40225 Düsseldorf, Germany

Author Information

  1. University of Tübingen, Laboratory for Neuroregeneration and Repair, Hertie Institute for Clinical Brain Research, Otfried-Müller-Strasse 27, 72076 Tübingen, Germany

Publication History

  1. Published Online: 16 JUN 2008
  2. Published Print: 20 FEB 2008

ISBN Information

Print ISBN: 9783527317073

Online ISBN: 9783527622467

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Keywords:

  • neural degeneration;
  • neural repair;
  • molecular pathways;
  • axon plasticity;
  • acute CNS injury;
  • mechanisms determine functional recovery;
  • gene expression changes;
  • gene expression profiles;
  • axon sprouting;
  • axon regeneration;
  • transcription factors;
  • therapeutic implications;
  • neurodegenerative disorders

Summary

This chapter contains sections titled:

  • Introduction

  • The Mechanisms that Determine Functional Recovery Following Acute CNS Damage

  • Repair and Tissue Plasticity Gene Expression Changes Following Acute CNS Injury

  • Gene Expression Profiles and Gene Clusters Related to Axon Sprouting and Regeneration

  • The Role of Transcription Factors in the Control of Axon Growth and Regeneration

  • Therapeutic Implications for Neurodegenerative Disorders

  • Future Perspectives

  • References