Chapter 4. Dynamic Kinetic Resolutions

  1. Prof. Vicente Gotor3,
  2. Prof. Ignacio Alfonso4 and
  3. Dr. Eduardo García-Urdiales5
  1. Belén Martín-Matute1,2 and
  2. Jan-E. Bäckvall2

Published Online: 17 JUN 2008

DOI: 10.1002/9783527622481.ch4

Asymmetric Organic Synthesis with Enzymes

Asymmetric Organic Synthesis with Enzymes

How to Cite

Martín-Matute, B. and Bäckvall, J.-E. (2008) Dynamic Kinetic Resolutions, in Asymmetric Organic Synthesis with Enzymes (eds V. Gotor, I. Alfonso and E. García-Urdiales), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622481.ch4

Editor Information

  1. 3

    Universidad de Oviedo, Facultad de Química, Departamento de Química Orgánica e Inorgánica, Julian Clavería 6, 33006 Oviedo, Spain

  2. 4

    Dept.de Química Orgánica/Inorg, Universidad Jaume I, Campus del Riu Sec, 12071 Castellón, Spain

  3. 5

    EMBL - Biocomputing, Meyerhofstr. 1, 69117 Heidelberg, Germany

Author Information

  1. 1

    Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain

  2. 2

    Stockholm University SE-106, Department of Organic Chemistry, Arrhenius Laboratory, 91 Stockholm, Sweden

Publication History

  1. Published Online: 17 JUN 2008
  2. Published Print: 20 FEB 2008

ISBN Information

Print ISBN: 9783527318254

Online ISBN: 9783527622481

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Keywords:

  • synthetic applications;
  • dynamic kinetic resolutions;
  • synthesis of enantiomerically pure compounds;
  • metal-catalyzed racemization;
  • base-catalyzed racemization;
  • acid-catalyzed racemization;
  • racemization catalyzed by aldehydes;
  • enzyme-catalyzed racemization

Summary

This chapter contains sections titled:

  • Introduction

  • Metal-Catalyzed Racemization

  • Base-Catalyzed Racemization

  • Acid-Catalyzed Racemization

  • Racemization through Continuous Reversible Formation–Cleavage of the Substrate

  • Racemization Catalyzed by Aldehydes

  • Enzyme-Catalyzed Racemization

  • Racemization through SN2 Displacement

  • Other Racemization Methods

  • Concluding Remarks

  • References