Chapter 15. Induction of Drug Metabolism: Role for Nuclear Receptors

  1. Prof. Dr. Eckhard Ottow2 and
  2. Dr. Hilmar Weinmann3
  1. Christoph Handschin

Published Online: 19 DEC 2008

DOI: 10.1002/9783527623297.ch15

Nuclear Receptors as Drug Targets

Nuclear Receptors as Drug Targets

How to Cite

Handschin, C. (2008) Induction of Drug Metabolism: Role for Nuclear Receptors, in Nuclear Receptors as Drug Targets (eds E. Ottow and H. Weinmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527623297.ch15

Editor Information

  1. 2

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/345), Müllerstrasse 178, 13342 Berlin, Germany

  2. 3

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/048A), Müllerstrasse 178, 13342 Berlin, Germany

Author Information

  1. University of Zurich, Institute of Physiology and Zurich, Center for Integrative Human Physiology, Winterthurerstrasse 190, 8057 Zurich, Switzerland

Publication History

  1. Published Online: 19 DEC 2008
  2. Published Print: 20 AUG 2008

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold4,
  2. Prof. Dr. Hugo Kubinyi5 and
  3. Prof. Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527318728

Online ISBN: 9783527623297

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Keywords:

  • drug metabolism;
  • nuclear receptors;
  • transcriptional regulation;
  • cytochrome P450;
  • bile acids

Summary

This chapter contains sections titled:

  • Introduction

  • PXR: Structure and Activation

  • CAR: Structure and Activation

  • Detoxification of Drugs and Other Xenobiotics

  • PXR and CAR Regulation of Bile Acid, Cholesterol and Bilirubin Metabolism

  • Xenobiotic-Sensing Nuclear Receptors in Cancer, Oxidative Stress and Pollution

  • CAR and PXR in Inflammation

  • Regulation of Glucose and Lipid Homeostasis by CAR and PXR

  • Conclusions and Perspectives

  • References