Chapter 15. Induction of Drug Metabolism: Role for Nuclear Receptors
- Prof. Dr. Eckhard Ottow2,
- Dr. Hilmar Weinmann3
Published Online: 19 DEC 2008
DOI: 10.1002/9783527623297.ch15
Copyright © 2008 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Nuclear Receptors as Drug Targets
Additional Information
How to Cite
Handschin, C. (2008) Induction of Drug Metabolism: Role for Nuclear Receptors, in Nuclear Receptors as Drug Targets (eds E. Ottow and H. Weinmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527623297.ch15
Editor Information
- 2
Bayer Schering Pharma AG, Medicinal Chemistry (S106/345), Müllerstrasse 178, 13342 Berlin, Germany
- 3
Bayer Schering Pharma AG, Medicinal Chemistry (S106/048A), Müllerstrasse 178, 13342 Berlin, Germany
Publication History
- Published Online: 19 DEC 2008
- Published Print: 20 AUG 2008
Book Series:
Book Series Editors:
- Prof. Dr. Raimund Mannhold4,
- Prof. Dr. Hugo Kubinyi5,
- Prof. Dr. Gerd Folkers6
Series Editor Information
- 4
Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany
- 5
Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany
- 6
Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland
ISBN Information
Print ISBN: 9783527318728
Online ISBN: 9783527623297
- Summary
- Chapter
- References
Keywords:
- drug metabolism;
- nuclear receptors;
- transcriptional regulation;
- cytochrome P450;
- bile acids
Summary
This chapter contains sections titled:
Introduction
PXR: Structure and Activation
CAR: Structure and Activation
Detoxification of Drugs and Other Xenobiotics
PXR and CAR Regulation of Bile Acid, Cholesterol and Bilirubin Metabolism
Xenobiotic-Sensing Nuclear Receptors in Cancer, Oxidative Stress and Pollution
CAR and PXR in Inflammation
Regulation of Glucose and Lipid Homeostasis by CAR and PXR
Conclusions and Perspectives
References