Chapter 2. Targeting the Nuclear Receptor–Cofactor Interaction

  1. Prof. Dr. Eckhard Ottow2 and
  2. Dr. Hilmar Weinmann3
  1. Belen Vaz,
  2. Sabine Möcklinghoff and
  3. Luc Brunsveld

Published Online: 19 DEC 2008

DOI: 10.1002/9783527623297.ch2

Nuclear Receptors as Drug Targets

Nuclear Receptors as Drug Targets

How to Cite

Vaz, B., Möcklinghoff, S. and Brunsveld, L. (2008) Targeting the Nuclear Receptor–Cofactor Interaction, in Nuclear Receptors as Drug Targets (eds E. Ottow and H. Weinmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527623297.ch2

Editor Information

  1. 2

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/345), Müllerstrasse 178, 13342 Berlin, Germany

  2. 3

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/048A), Müllerstrasse 178, 13342 Berlin, Germany

Author Information

  1. Chemical Genomics Center, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany

Publication History

  1. Published Online: 19 DEC 2008
  2. Published Print: 20 AUG 2008

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold4,
  2. Prof. Dr. Hugo Kubinyi5 and
  3. Prof. Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527318728

Online ISBN: 9783527623297

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Keywords:

  • nuclear receptors;
  • cofactors;
  • coactivators;
  • peptides;
  • LXXLL motif;
  • protein–protein interactions;
  • inhibitors of protein–protein interactions

Summary

This chapter contains sections titled:

  • Introduction

  • Evaluation of the Nuclear Receptor–Cofactor Interaction as a Drug Target

  • Inhibitors of the Nuclear Receptor–Cofactor Interaction

  • Perspectives

  • References