Chapter 5. Estrogen Receptors as Therapeutic Targets in Breast Cancer

  1. Prof. Dr. Eckhard Ottow2 and
  2. Dr. Hilmar Weinmann3
  1. Eric A. Ariazi and
  2. V. Craig Jordan

Published Online: 19 DEC 2008

DOI: 10.1002/9783527623297.ch5

Nuclear Receptors as Drug Targets

Nuclear Receptors as Drug Targets

How to Cite

Ariazi, E. A. and Jordan, V. C. (2008) Estrogen Receptors as Therapeutic Targets in Breast Cancer, in Nuclear Receptors as Drug Targets (eds E. Ottow and H. Weinmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527623297.ch5

Editor Information

  1. 2

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/345), Müllerstrasse 178, 13342 Berlin, Germany

  2. 3

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/048A), Müllerstrasse 178, 13342 Berlin, Germany

Author Information

  1. Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA

Publication History

  1. Published Online: 19 DEC 2008
  2. Published Print: 20 AUG 2008

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold4,
  2. Prof. Dr. Hugo Kubinyi5 and
  3. Prof. Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527318728

Online ISBN: 9783527623297

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Keywords:

  • estrogen receptors;
  • therapeutic targets;
  • breast cancer;
  • hormone replacement therapy;
  • tamoxifen

Summary

This chapter contains sections titled:

  • Introduction

  • Biology of ERs

  • Therapeutic Basis for Targeting ER

  • SERMs

  • Mechanisms of Action of SERMS

  • Additional SERMs

  • Pure Antiestrogens

  • Conclusions

  • References