Chapter 7. Progesterone Receptor Antagonists

  1. Prof. Dr. Eckhard Ottow2 and
  2. Dr. Hilmar Weinmann3
  1. Irving M. Spitz

Published Online: 19 DEC 2008

DOI: 10.1002/9783527623297.ch7

Nuclear Receptors as Drug Targets

Nuclear Receptors as Drug Targets

How to Cite

Spitz, I. M. (2008) Progesterone Receptor Antagonists, in Nuclear Receptors as Drug Targets (eds E. Ottow and H. Weinmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527623297.ch7

Editor Information

  1. 2

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/345), Müllerstrasse 178, 13342 Berlin, Germany

  2. 3

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/048A), Müllerstrasse 178, 13342 Berlin, Germany

Author Information

  1. Ben Gurion University of the Negev, Institute of Hormone Research, 14 Nili Street, Jerusalem 92548, Israel

Publication History

  1. Published Online: 19 DEC 2008
  2. Published Print: 20 AUG 2008

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold4,
  2. Prof. Dr. Hugo Kubinyi5 and
  3. Prof. Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527318728

Online ISBN: 9783527623297

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Keywords:

  • progesterone receptor antagonists (PAs);
  • selective progesterone receptor modulators (SPRMs);
  • progesterone receptor modulators (PRMs)

Summary

This chapter contains sections titled:

  • Introduction

  • Chemistry

  • Progesterone Receptor (PR)

  • Mechanism of Action

  • Biological Effects of PAs and SPRMs

  • Clinical Applications

  • Other Potential Obstetrical and Gynecological Applications

  • Nongynecological Applications

  • Side-Effects of Long-Term Administration of PAs and SPRMs

  • Conclusions

  • References