Chapter 8. Nonsteroidal Tissue-Selective Androgen Receptor Modulators

  1. Prof. Dr. Eckhard Ottow2 and
  2. Dr. Hilmar Weinmann3
  1. Michael L. Mohler,
  2. Casey E. Bohl,
  3. Ramesh Narayanan,
  4. Yali He,
  5. Dong Jin Hwang,
  6. James T. Dalton and
  7. Duane D. Miller

Published Online: 19 DEC 2008

DOI: 10.1002/9783527623297.ch8

Nuclear Receptors as Drug Targets

Nuclear Receptors as Drug Targets

How to Cite

Mohler, M. L., Bohl, C. E., Narayanan, R., He, Y., Hwang, D. J., Dalton, J. T. and Miller, D. D. (2008) Nonsteroidal Tissue-Selective Androgen Receptor Modulators, in Nuclear Receptors as Drug Targets (eds E. Ottow and H. Weinmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527623297.ch8

Editor Information

  1. 2

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/345), Müllerstrasse 178, 13342 Berlin, Germany

  2. 3

    Bayer Schering Pharma AG, Medicinal Chemistry (S106/048A), Müllerstrasse 178, 13342 Berlin, Germany

Author Information

  1. GTx, Inc., Preclinical Research and Development, 3 North Dunlap Street, Memphis, TN 38163, USA

Publication History

  1. Published Online: 19 DEC 2008
  2. Published Print: 20 AUG 2008

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold4,
  2. Prof. Dr. Hugo Kubinyi5 and
  3. Prof. Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527318728

Online ISBN: 9783527623297

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Keywords:

  • androgen receptor;
  • nonsteroidal androgen;
  • selective androgen receptor modulator;
  • SARM;
  • anabolic agent;
  • sarcopenia;
  • osteoporosis;
  • cancer cachexia

Summary

This chapter contains sections titled:

  • Introduction

  • Nonsteroidal AR Ligands

  • Molecular Basis for SARM Activities

  • SARMs: A Promising Class of Clinical and Preclinical Candidates

  • References