Chapter 15. Altered Immune Status and Leukocytes Reprogramming

  1. Prof. Dr. Jean-Marc Cavaillon2 and
  2. Dr. Christophe Adrie3
  1. Prof. Dr. Jean-Marc Cavaillon2,
  2. Minou Adib-Conquy1 and
  3. Dr. Christophe Adrie3

Published Online: 25 MAY 2009

DOI: 10.1002/9783527626151.ch15

Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care

Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care

How to Cite

Cavaillon, J.-M., Adib-Conquy, M. and Adrie, C. (2008) Altered Immune Status and Leukocytes Reprogramming, in Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care (eds J.-M. Cavaillon and C. Adrie), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527626151.ch15

Editor Information

  1. 2

    Unit Cytokines et Inflammation, Institut Pasteur, 28, rue Dr. Roux, 75015 Paris, France

  2. 3

    Hôpital Delafontaine, Réanimation Polyvalente, 2 rue du Docteur Delafontaine, 93205 Saint-Denis, France

Author Information

  1. 1

    Institut Pasteur, Unit Cytokines & Inflammation, Paris, France

  2. 2

    Unit Cytokines et Inflammation, Institut Pasteur, 28, rue Dr. Roux, 75015 Paris, France

  3. 3

    Hôpital Delafontaine, Réanimation Polyvalente, 2 rue du Docteur Delafontaine, 93205 Saint-Denis, France

Publication History

  1. Published Online: 25 MAY 2009
  2. Published Print: 15 OCT 2008

ISBN Information

Print ISBN: 9783527319350

Online ISBN: 9783527626151

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Keywords:

  • Immune status;
  • leukocyte reprogramming;
  • cell surface markers;
  • cytokine production;
  • whole blood assay;
  • monocytes

Summary

The counter-regulatory mechanisms initiated to limit the overzealous inflammatory process in patients with infectious (sepsis) or non-infectious systemic inflammatory response syndrome (SIRS) led to the concept of “compensatory anti-inflammatory response syndrome” (CARS). One major consequence of CARS is the modification of the immune status that could favor the enhanced susceptibility of intensive care patients to nosocomial infections. The expression of surface markers can be modified, and numerous functions of circulating leukocytes are altered in sepsis and SIRS patients, as well as in animal models of sepsis or SIRS. However, this is rather a reprogramming of circulating leukocytes, since there is not a global defect of the immune cells functions.