Chapter 5. Pathogens in Sepsis: Gram-Negative Bacterial PAMPs and PRRs

  1. Prof. Dr. Jean-Marc Cavaillon2 and
  2. Dr. Christophe Adrie3
  1. Andra Schromm,
  2. Christian Alexander,
  3. Thomas Gutsmann,
  4. Jörg Andrä and
  5. Cordula Stamme

Published Online: 25 MAY 2009

DOI: 10.1002/9783527626151.ch5

Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care

Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care

How to Cite

Schromm, A., Alexander, C., Gutsmann, T., Andrä, J. and Stamme, C. (2008) Pathogens in Sepsis: Gram-Negative Bacterial PAMPs and PRRs, in Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care (eds J.-M. Cavaillon and C. Adrie), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527626151.ch5

Editor Information

  1. 2

    Unit Cytokines et Inflammation, Institut Pasteur, 28, rue Dr. Roux, 75015 Paris, France

  2. 3

    Hôpital Delafontaine, Réanimation Polyvalente, 2 rue du Docteur Delafontaine, 93205 Saint-Denis, France

Author Information

  1. Leibniz-Center for Medicine and Biosciences, Research Center Borstel, Borstel, Germany

Publication History

  1. Published Online: 25 MAY 2009
  2. Published Print: 15 OCT 2008

ISBN Information

Print ISBN: 9783527319350

Online ISBN: 9783527626151

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Keywords:

  • gram-negative bacteria (GNB);
  • pathogen-associated molecular patterns (PAMPs);
  • pattern recognition receptors (PRRs);
  • innate immunity;
  • lipopolysaccharide (LPS);
  • immune response;
  • endotoxic conformation

Summary

This chapter contains sections titled:

  • Introduction

  • Pathogen-associated Molecular Pattern (PAMP) Molecules of GNB

  • The LPS-activated TLR4/MD-2-signaling system: Central PRR Signaling Pathways and Negative Regulatory Factors

  • Endotoxic Activity of Enterobacterial LPS is determined by Physico-chemical Properties

  • Modulation of Biological Activity of LPS

  • Therapeutic Approaches

  • Acknowledgments

  • References