Chapter 6. Pathogens in Sepsis: Gram-Positive Bacterial PAMPs, PRRs and Superantigens

  1. Prof. Dr. Jean-Marc Cavaillon2 and
  2. Dr. Christophe Adrie3
  1. Christian Alexander,
  2. Romney Haylett,
  3. Andra Schromm,
  4. Ulrich Zähringer and
  5. Lothar Rink

Published Online: 25 MAY 2009

DOI: 10.1002/9783527626151.ch6

Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care

Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care

How to Cite

Alexander, C., Haylett, R., Schromm, A., Zähringer, U. and Rink, L. (2009) Pathogens in Sepsis: Gram-Positive Bacterial PAMPs, PRRs and Superantigens, in Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care (eds J.-M. Cavaillon and C. Adrie), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527626151.ch6

Editor Information

  1. 2

    Unit Cytokines et Inflammation, Institut Pasteur, 28, rue Dr. Roux, 75015 Paris, France

  2. 3

    Hôpital Delafontaine, Réanimation Polyvalente, 2 rue du Docteur Delafontaine, 93205 Saint-Denis, France

Author Information

  1. Leibniz-Center for Medicine and Biosciences, Research Center Borstel, Borstel, Germany

Publication History

  1. Published Online: 25 MAY 2009
  2. Published Print: 15 OCT 2008

ISBN Information

Print ISBN: 9783527319350

Online ISBN: 9783527626151

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Keywords:

  • Gram-positive bacteria;
  • Firmicutes;
  • Bacterial superantigens;
  • Immunorecognition;
  • Biofilm;
  • Toxic shock;
  • Streptococcal toxic shock syndrome (STSS)

Summary

This chapter contains sections titled:

  • Introduction

  • Pathogen-associated Molecular Pattern (PAMP) Molecules of Gram-positive Bacteria

  • Activation of TLR2-dependent Signaling by Lipoproteins of Gram-positive Bacteria: Central Signaling Pathways and Major Negative Regulatory Factors

  • Superantigens: A Specific Class of Gram-positive Pathogenicity Factors

  • Novel Therapeutic Concepts in Gram-positive Septic Diseases

  • Acknowledgments

  • References