Chapter 9. Apoptosis: A Potential Therapeutic Target in Sepsis and Non-Infectious Systemic Inflammation

  1. Prof. Dr. Jean-Marc Cavaillon3 and
  2. Dr. Christophe Adrie4
  1. Chun-Shiang Chung1,
  2. Ryan Swan1,
  3. Mario Perl1,
  4. Doreen E. Wesche-Soldato1 and
  5. Alfred Ayala2

Published Online: 25 MAY 2009

DOI: 10.1002/9783527626151.ch9

Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care

Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care

How to Cite

Chung, C.-S., Swan, R., Perl, M., Wesche-Soldato, D. E. and Ayala, A. (2008) Apoptosis: A Potential Therapeutic Target in Sepsis and Non-Infectious Systemic Inflammation, in Sepsis and Non-Infectious Systemic Inflammation: From Biology to Critical Care (eds J.-M. Cavaillon and C. Adrie), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527626151.ch9

Editor Information

  1. 3

    Unit Cytokines et Inflammation, Institut Pasteur, 28, rue Dr. Roux, 75015 Paris, France

  2. 4

    Hôpital Delafontaine, Réanimation Polyvalente, 2 rue du Docteur Delafontaine, 93205 Saint-Denis, France

Author Information

  1. 1

    Rhode Island Hospital/Brown University, School of Medicine, Department of Surgery, Providence, USA

  2. 2

    Rhode Island Hospital, Division of Surgical Research Providence, USA

Publication History

  1. Published Online: 25 MAY 2009
  2. Published Print: 15 OCT 2008

ISBN Information

Print ISBN: 9783527319350

Online ISBN: 9783527626151

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Keywords:

  • sepsis;
  • mice;
  • human;
  • apoptosis;
  • death-receptor pathway;
  • mitochondrial pathway;
  • caspase

Summary

This chapter contains sections titled:

  • Introduction

  • Apoptosis

  • Pathological Role of Apoptotic Cell Death in Sepsis

  • Potential Anti-apoptotic Therapies for the Treatment of Sepsis

  • Conclusions

  • Acknowledgments

  • References