Chapter 21. Preneoplastic Models and Carcinogenicity Studies with Rodents

  1. Prof. Dr. Siegfried Knasmüller1,
  2. Dr. David M. DeMarini2,
  3. Prof. Ian Johnson3 and
  4. Dr. Clarissa Gerhäuser4,5
  1. Veronika A. Ehrlich and
  2. Prof. Dr. Siegfried Knasmüller

Published Online: 16 JUL 2009

DOI: 10.1002/9783527626588.ch21

Chemoprevention of Cancer and DNA Damage by Dietary Factors

Chemoprevention of Cancer and DNA Damage by Dietary Factors

How to Cite

Ehrlich, V. A. and Knasmüller, S. (2009) Preneoplastic Models and Carcinogenicity Studies with Rodents, in Chemoprevention of Cancer and DNA Damage by Dietary Factors (eds S. Knasmüller, D. M. DeMarini, I. Johnson and C. Gerhäuser), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527626588.ch21

Editor Information

  1. 1

    Medical University of Vienna, Department of Medicine I, Institute of Cancer Research, Borschkegasse 8a, 1090 Vienna, Austria

  2. 2

    U.S. Environmental Protection Agency, Environmental Carcinogenesis Division, Research Triangle Park, NC 27711, USA

  3. 3

    Institute of Food Research, Intestinal Biology and Health Programme, Norwich Research Park, Colney, Norwich NR4 7UA, UK

  4. 4

    German Cancer Research Centre (DKFZ), Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

  5. 5

    German Cancer Research Center, Division of Epigenomics and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

Author Information

  1. Medical University of Vienna, Department of Medicine I, Institute of Cancer Research, Borschkegasse 8a, 1090 Vienna, Austria

Publication History

  1. Published Online: 16 JUL 2009
  2. Published Print: 25 MAR 2009

ISBN Information

Print ISBN: 9783527320585

Online ISBN: 9783527626588

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Keywords:

  • aberrant crypt foci;
  • animal models;
  • carcinogens;
  • chemopreventive activity;
  • rodents

Summary

This chapter contains sections titled:

  • Introduction

  • Animal Models Based on the Use of Carcinogens

  • Genetically Engineered Rodent Models Used in Cancer Prevention Studies

  • Xenograft Models

  • Conclusions

  • Acknowledgments

  • References