Chapter 5. Gonadotropins and the Importance of Glycosylation

  1. Prof. Dr. Gary Walsh
  1. Alfredo Ulloa-Aguirre1,
  2. James A. Dias2,3 and
  3. George R. Bousfield4

Published Online: 25 SEP 2009

DOI: 10.1002/9783527626601.ch5

Post-translational Modification of Protein Biopharmaceuticals

Post-translational Modification of Protein Biopharmaceuticals

How to Cite

Ulloa-Aguirre, A., Dias, J. A. and Bousfield, G. R. (2009) Gonadotropins and the Importance of Glycosylation, in Post-translational Modification of Protein Biopharmaceuticals (ed G. Walsh), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527626601.ch5

Editor Information

  1. Industrial Biochemistry Program, CES Department, University of Limerick, Castletroy, Limerick City, Ireland

Author Information

  1. 1

    Hospital de Gineco-Obstetricia “Luis Castelazo Ayala”, Research Unit in Reproductive Medicine, Instituto Mexicano del Seguro Social, Mexico D.F., Mexico

  2. 2

    State University of New York at Albany, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA

  3. 3

    Department of Biomedical Sciences, Wadsworth Center, David Axelrod Institute for Public Health, 120 New Scotland Ave, Albany, NY 12208, USA

  4. 4

    Wichita State University, Department of Biological Sciences, 1845 Fairmount, Wichita, KS 67260, USA

Publication History

  1. Published Online: 25 SEP 2009
  2. Published Print: 15 APR 2009

ISBN Information

Print ISBN: 9783527320745

Online ISBN: 9783527626601

SEARCH

Keywords:

  • gonadotropins;
  • glycans;
  • glycoprotein hormones;
  • glycosylation;
  • therapeutics

Summary

This chapter contains sections titled:

  • Introduction

  • Structure of Gonadotropins

  • Glycosylation of Gonadotropins and Structural Microheterogeneity

  • Role of Glycosylation in the Function of Gonadotropins

  • Regulation of Gonadotropin Glycosylation

  • Therapeutic Applications of Gonadotropins

  • Conclusions

  • References