Chapter 1. New Frontiers in Epigenetic Modifications

  1. Prof., Dr. Wolfgang Sippl3 and
  2. Prof., Dr. Manfred Jung4
  1. Adam L. Garske1 and
  2. John M. Denu2

Published Online: 25 FEB 2010

DOI: 10.1002/9783527627073.ch1

Epigenetic Targets in Drug Discovery, Volume 42

Epigenetic Targets in Drug Discovery, Volume 42

How to Cite

Garske, A. L. and Denu, J. M. (2009) New Frontiers in Epigenetic Modifications, in Epigenetic Targets in Drug Discovery, Volume 42 (eds W. Sippl and M. Jung), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527627073.ch1

Editor Information

  1. 3

    Institut für Pharmazie, Martin-Luther-Universität, Wolfgang-Langenbeck-Straße 4, 06120 Halle, Germany

  2. 4

    Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität, Albertstraße 25, 79104 Freiburg, Germany

Author Information

  1. 1

    University of Wisconsin, Department of Chemistry Madison, WI 53706, USA

  2. 2

    University of Wisconsin, Department of Biomolecular Chemistry Madison, WI 53706, USA

Publication History

  1. Published Online: 25 FEB 2010
  2. Published Print: 24 JUN 2009

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof., Dr. Raimund Mannhold5,
  2. Prof., Dr. Hugo Kubinyi6 and
  3. Prof., Dr. Gerd Folkers7

Series Editor Information

  1. 5

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany

  2. 6

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 7

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527323555

Online ISBN: 9783527627073

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Keywords:

  • histone code;
  • chromatin;
  • posttranslational modifications;
  • epigenetics

Summary

This chapter contains sections titled:

  • Introduction

  • DNA Methylation

  • Histone Modifications and the Histone Code Hypothesis

  • Origins of Specificity in Histone Binding Proteins/Modifying Enzymes

  • Histone Modification Cross-talk

  • Inhibitors of DNMTs and HDACs

  • Conclusions

  • References