Chapter 10. NAD-Dependent Deacetylases as Therapeutic Targets

  1. Prof., Dr. Wolfgang Sippl2 and
  2. Prof., Dr. Manfred Jung3
  1. Hongzhe Li,
  2. Julian Simon and
  3. Antonio Bedalov

Published Online: 25 FEB 2010

DOI: 10.1002/9783527627073.ch10

Epigenetic Targets in Drug Discovery, Volume 42

Epigenetic Targets in Drug Discovery, Volume 42

How to Cite

Li, H., Simon, J. and Bedalov, A. (2009) NAD-Dependent Deacetylases as Therapeutic Targets, in Epigenetic Targets in Drug Discovery, Volume 42 (eds W. Sippl and M. Jung), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527627073.ch10

Editor Information

  1. 2

    Institut für Pharmazie, Martin-Luther-Universität, Wolfgang-Langenbeck-Straße 4, 06120 Halle, Germany

  2. 3

    Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität, Albertstraße 25, 79104 Freiburg, Germany

Author Information

  1. Fred Hutchinson, Cancer Research Center, 1100 Fairview Ave. N. Seattle, WA 98109, USA

Publication History

  1. Published Online: 25 FEB 2010
  2. Published Print: 24 JUN 2009

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof., Dr. Raimund Mannhold4,
  2. Prof., Dr. Hugo Kubinyi5 and
  3. Prof., Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527323555

Online ISBN: 9783527627073

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Keywords:

  • NAD-dependent deacetylases;
  • sirtuin

Summary

This chapter contains sections titled:

  • Historical Perspective and Functions of Sir2 in Yeast

  • Sirtuin Enzymatic Activity and its Modulation by Endogenous Molecules

  • Small Molecule Inhibitors of Sirtuins

  • Small Molecule Activators of Sirtuins

  • SIRT1 as a Therapeutic Target in Metabolic Syndrome and Type 2 Diabetes

  • Neurological Diseases

  • Conclusion

  • References