Chapter 2. Structural Biology of Epigenetic Targets

  1. Prof., Dr. Wolfgang Sippl2 and
  2. Prof., Dr. Manfred Jung3
  1. Christophe Romier,
  2. Jean-Marie Wurtz,
  3. Jean-Paul Renaud and
  4. Jean Cavarelli

Published Online: 25 FEB 2010

DOI: 10.1002/9783527627073.ch2

Epigenetic Targets in Drug Discovery, Volume 42

Epigenetic Targets in Drug Discovery, Volume 42

How to Cite

Romier, C., Wurtz, J.-M., Renaud, J.-P. and Cavarelli, J. (2009) Structural Biology of Epigenetic Targets, in Epigenetic Targets in Drug Discovery, Volume 42 (eds W. Sippl and M. Jung), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527627073.ch2

Editor Information

  1. 2

    Institut für Pharmazie, Martin-Luther-Universität, Wolfgang-Langenbeck-Straße 4, 06120 Halle, Germany

  2. 3

    Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität, Albertstraße 25, 79104 Freiburg, Germany

Author Information

  1. IGBMC (Institut de Génétique et de, Biologie Moléculaire et Cellulaire, UMR7104 CNRS-UDS, INSERM U964) Département de Biologie et Génomique Structurales, 1 rue Laurent Fries, 67404 Illkirch, France

Publication History

  1. Published Online: 25 FEB 2010
  2. Published Print: 24 JUN 2009

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof., Dr. Raimund Mannhold4,
  2. Prof., Dr. Hugo Kubinyi5 and
  3. Prof., Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527323555

Online ISBN: 9783527627073

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Keywords:

  • epigenetics;
  • structural knowledge;
  • histone-modifying enzymes

Summary

This chapter contains sections titled:

  • Introduction

  • Histone Acetyltransferases

  • Histone Deacetylases

  • Sirtuins

  • Histone Methylation Enzymes

  • Histone Demethylases

  • DNA Methyltransferases

  • Concluding Remarks: the Challenge of Structural Studies of Epigenetic Targets

  • References