Chapter 3. Computer- and Structure-Based Lead Identification for Epigenetic Targets

  1. Prof., Dr. Wolfgang Sippl1 and
  2. Prof., Dr. Manfred Jung2
  1. Ralf Heinke,
  2. Urszula Uciechowska and
  3. Prof., Dr. Wolfgang Sippl

Published Online: 25 FEB 2010

DOI: 10.1002/9783527627073.ch3

Epigenetic Targets in Drug Discovery, Volume 42

Epigenetic Targets in Drug Discovery, Volume 42

How to Cite

Heinke, R., Uciechowska, U. and Sippl, W. (2009) Computer- and Structure-Based Lead Identification for Epigenetic Targets, in Epigenetic Targets in Drug Discovery, Volume 42 (eds W. Sippl and M. Jung), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527627073.ch3

Editor Information

  1. 1

    Institut für Pharmazie, Martin-Luther-Universität, Wolfgang-Langenbeck-Straße 4, 06120 Halle, Germany

  2. 2

    Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität, Albertstraße 25, 79104 Freiburg, Germany

Author Information

  1. Institut für Pharmazie, Martin-Luther-Universität, Wolfgang-Langenbeck-Straße 4, 06120 Halle, Germany

Publication History

  1. Published Online: 25 FEB 2010
  2. Published Print: 24 JUN 2009

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof., Dr. Raimund Mannhold3,
  2. Prof., Dr. Hugo Kubinyi4 and
  3. Prof., Dr. Gerd Folkers5

Series Editor Information

  1. 3

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany

  2. 4

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 5

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527323555

Online ISBN: 9783527627073

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Keywords:

  • computer-based design;
  • ligand docking;
  • epigenetic target structures

Summary

This chapter contains sections titled:

  • Introduction

  • Computer-Based Methods in Drug Discovery

  • DNA Methyltransferases

  • Histone Deacetylases

  • Histone Acetyltransferases

  • Histone Methyltransferases

  • Histone Demethylases

  • Summary

  • References