Chapter 6. Epigenetic Targets in Drug Discovery: Cell-Based Assays for HDAC Inhibitor Hit Validation

  1. Prof., Dr. Wolfgang Sippl2 and
  2. Prof., Dr. Manfred Jung3
  1. Mira Jung,
  2. Kwon-Jeong Yong,
  3. Alfredo Velena and
  4. Sung Lee

Published Online: 25 FEB 2010

DOI: 10.1002/9783527627073.ch6

Epigenetic Targets in Drug Discovery, Volume 42

Epigenetic Targets in Drug Discovery, Volume 42

How to Cite

Jung, M., Yong, K.-J., Velena, A. and Lee, S. (2009) Epigenetic Targets in Drug Discovery: Cell-Based Assays for HDAC Inhibitor Hit Validation, in Epigenetic Targets in Drug Discovery, Volume 42 (eds W. Sippl and M. Jung), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527627073.ch6

Editor Information

  1. 2

    Institut für Pharmazie, Martin-Luther-Universität, Wolfgang-Langenbeck-Straße 4, 06120 Halle, Germany

  2. 3

    Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität, Albertstraße 25, 79104 Freiburg, Germany

Author Information

  1. Georgetown University, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Division of Radiation Research, Washington, DC 20057, USA

Publication History

  1. Published Online: 25 FEB 2010
  2. Published Print: 24 JUN 2009

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof., Dr. Raimund Mannhold4,
  2. Prof., Dr. Hugo Kubinyi5 and
  3. Prof., Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527323555

Online ISBN: 9783527627073

SEARCH

Keywords:

  • epigenetics;
  • histone deacetylase inhibitors

Summary

This chapter contains sections titled:

  • Introduction

  • In Vitro Assays for HDAC Inhibitors

  • Cell-Based Assays

  • Biological Function-Based Assays

  • HDAC Isoform Functional Assays

  • Anticancer Activity

  • Perspective

  • References