Chapter 6. Membrane Permeability – Measurement and Prediction in Drug Discovery

  1. Prof., Dr. Bernard Faller3,
  2. Dr. Laszlo Urban4
  1. Kiyohiko Sugano1,
  2. Lourdes Cucurull-Sanchez2,
  3. Joanne Bennett1

Published Online: 2 MAR 2010

DOI: 10.1002/9783527627448.ch6

Book Title

Hit and Lead Profiling: Identification and Optimization of Drug-like Molecules, Volume 43

Hit and Lead Profiling: Identification and Optimization of Drug-like Molecules, Volume 43

Additional Information

How to Cite

Sugano, K., Cucurull-Sanchez, L. and Bennett, J. (2010) Membrane Permeability – Measurement and Prediction in Drug Discovery, in Hit and Lead Profiling: Identification and Optimization of Drug-like Molecules, Volume 43 (eds B. Faller and L. Urban), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527627448.ch6

Editor Information

  1. 3

    Novartis Institutes for BioMedical Research, Novartis Campus, WSJ-350.3.04, Forum 1, 4002 Basel, Switzerland

  2. 4

    Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Ave., Cambridge, MA 02139, USA

Author Information

  1. 1

    Pfizer Global Research & Development Research Formulation Sandwich, Kent CT13 9NJ, UK

  2. 2

    Pfizer Global Research & Development Pharmacokinetics, Dynamics and Metabolism, Sandwich, Kent CT13 9NJ, UK

Publication History

  1. Published Online: 2 MAR 2010
  2. Published Print: 19 AUG 2009

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof., Dr. Raimund Mannhold5,
  2. Prof., Dr. Hugo Kubinyi6,
  3. Prof., Dr. Gerd Folkers7

Series Editor Information

  1. 5

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 6

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 7

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527323319

Online ISBN: 9783527627448

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CHAPTER TOOLS

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Keywords:

  • pharmacokinetics;
  • membrane permeation;
  • intestinal barrier;
  • blood–brain barrier (BBB);
  • in silico prediction

Summary

This chapter contains sections titled:

  • Overview of Membrane Permeation

  • In Vitro Cell Models

  • Artificial Membranes

  • Limitation of In Vitro Assays

  • Computational Approaches/In Silico Modeling

  • Outlook

  • References

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