Chapter 1. General Insights into Tumor Invasion, Progression, and Metastasis

  1. Prof. Dr. Heike Allgayer PhD1,
  2. Prof. Dr. Helga Rehder2 and
  3. Prof. Dr. Simone Fulda3
  1. Prof. Dr. Heike Allgayer PhD

Published Online: 21 AUG 2009

DOI: 10.1002/9783527627523.ch1

Hereditary Tumors: From Genes to Clinical Consequences

Hereditary Tumors: From Genes to Clinical Consequences

How to Cite

Allgayer, H. (2008) General Insights into Tumor Invasion, Progression, and Metastasis, in Hereditary Tumors: From Genes to Clinical Consequences (eds H. Allgayer, H. Rehder and S. Fulda), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527627523.ch1

Editor Information

  1. 1

    University of Heidelberg and DKFZ (German Cancer Research Center) Heidelberg, Medical Faculty Mannheim, Chair of Experimental Surgery, Theodor-Kutzer-Ufer 1–3, 68167 Mannheim, Germany

  2. 2

    Medical University Vienna, Department of Medical Genetics, Währinger Strasse 10, 1090 Wien, Austria

  3. 3

    Ulm University Children's Hospital, Eythstrasse 24, 89075 Ulm, Germany

Author Information

  1. University of Heidelberg and DKFZ (German Cancer Research Center) Heidelberg, Medical Faculty Mannheim, Chair of Experimental Surgery, Theodor-Kutzer-Ufer 1–3, 68167 Mannheim, Germany

Publication History

  1. Published Online: 21 AUG 2009
  2. Published Print: 17 DEC 2008

ISBN Information

Print ISBN: 9783527320288

Online ISBN: 9783527627523

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Keywords:

  • invasion;
  • metastasis;
  • migration;
  • metastatic cascade;
  • angiogenesis

Summary

Invasion, progression, and metastasis are the hallmarks of malignant tumors, regardless of potentially hereditary compounds. Therefore, this introductory chapter will give a general overview of the major steps of the metastatic cascade, outline major phenomena contributing to metastasis, and introduce major molecules promoting these processes. Finally, current preliminary knowledge on potentially hereditary aspects of these molecules will be briefly discussed. However, this particular aspect is in desperate need of extensive further investigation.