Chapter 9. Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1α

  1. Jun. -Prof. Dr. Claus Jacob Junior Professor lecturer coordinator2 and
  2. Prof. Dr. Paul G. Winyard Professor chair visiting professor3
  1. Adam J. Case MD, PhD and
  2. Frederick E. Domann PhD professor

Published Online: 28 MAY 2009

DOI: 10.1002/9783527627585.ch9

Redox Signaling and Regulation in Biology and Medicine

Redox Signaling and Regulation in Biology and Medicine

How to Cite

Case, A. J. and Domann, F. E. (2009) Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1α, in Redox Signaling and Regulation in Biology and Medicine (eds C. Jacob and P. G. Winyard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527627585.ch9

Editor Information

  1. 2

    Universität des Saarlandes, Bioorgan. Chemie-Geb.B21, Campus, 66123 Saarbrücken, Germany

  2. 3

    University of Exeter, Biomedical & Clinical Science, St. Luke's Campus, Exeter EX1 2LU, United Kingdom

Author Information

  1. The University of Iowa, Holden Comprehensive Cancer Center, Carver College of Medicine, Department of Radiation Oncology, Iowa City, IA 52242-1181, USA

Publication History

  1. Published Online: 28 MAY 2009
  2. Published Print: 22 APR 2009

ISBN Information

Print ISBN: 9783527319251

Online ISBN: 9783527627585

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Keywords:

  • cancer;
  • DNA-binding domain;
  • HIF-1;
  • hypoxia;
  • posttranslational modification;
  • transcription factors;
  • VHL;
  • von Hippel–Lindau disease

Summary

This chapter contains sections titled:

  • Introduction

  • The Proteins and Mechanism

  • Hypoxia Inducible Factor Target Genes

  • Non-Hypoxia-Induced Activation of Hypoxia Inducible Factor

  • Diseases Involving Hypoxia Inducible Factor

  • The Promise of Hypoxia Inducible Factor-Targeted Therapies

  • Conclusions

  • References