Chapter 1. Endogenous DNA Damage

  1. Prof. Peter J. O'Brien3 and
  2. Prof. W. Robert Bruce4,5
  1. Erin G. Prestwich1 and
  2. Peter C. Dedon1,2

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch1

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Prestwich, E. G. and Dedon, P. C. (2009) Endogenous DNA Damage, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch1

Editor Information

  1. 3

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 4

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 5

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. 1

    Massachusetts Institute of Technology, Department of Biological, Engineering, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

  2. 2

    Massachusetts Institute of Technology, Center for Environmental Health Sciences, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100

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Keywords:

  • base oxidation;
  • tandem lesion;
  • lipid peroxidation;
  • base adduct;
  • base deamination;
  • base halogenation;
  • inflammation;
  • 2-deoxyribose oxidation;
  • endogenous electrophiles

Summary

This chapter contains sections titled:

  • Introduction

  • Oxidatively Damaged DNA

  • DNA Alkylation by Endogenous Electrophiles

  • DNA and RNA Deamination

  • Summary

  • References