Chapter 17. Polyglutamine Neuropathies: Animal Models to Molecular Mechanisms

  1. Prof. Peter J. O'Brien2 and
  2. Prof. W. Robert Bruce3,4
  1. Kelvin Hui and
  2. Jeffrey Henderson

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch17

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Hui, K. and Henderson, J. (2009) Polyglutamine Neuropathies: Animal Models to Molecular Mechanisms, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch17

Editor Information

  1. 2

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 3

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 4

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. University of Toronto, Faculty of Pharmacy, 27 King's College Circle, Toronto, Ontario M5S 1A1, Canada

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100

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Keywords:

  • polyglutamine neuropathy;
  • DRPLA;
  • spinocerebellar ataxia;
  • huntingtin protein;
  • ubiquitin;
  • proteasome

Summary

This chapter contains sections titled:

  • Neurobiology of Polyglutamine Diseases

  • Animal Models of Polyglutamine Diseases

  • Mechanisms of Polyglutamine-Induced Neural Injury

  • Future Perspectives

  • Acknowledgments

  • References