Chapter 21. Nutrient-Derived Endogenous Toxins in the Pathogenesis of Type 2 Diabetes at the β-Cell Level

  1. Prof. Peter J. O'Brien4 and
  2. Prof. W. Robert Bruce5,6
  1. Christine Tang1,
  2. Andrei I. Oprescu2 and
  3. Adria Giacca1,2,3

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch21

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Tang, C., Oprescu, A. I. and Giacca, A. (2009) Nutrient-Derived Endogenous Toxins in the Pathogenesis of Type 2 Diabetes at the β-Cell Level, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch21

Editor Information

  1. 4

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 5

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 6

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. 1

    University of Toronto, Department of Physiology, Faculty of Medicine, 1 King's College Circle, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada

  2. 2

    University of Toronto, Institute of Medical Science, Faculty of Medicine, 1 King's College Circle, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada

  3. 3

    University of Toronto, Department of Medicine, 1 King's College Circle, Medical Sciences Building Toronto, Ontario M5S 1A8 Canada

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100

SEARCH

Keywords:

  • type 2 diabetes;
  • β-cell glucotoxicity;
  • β-cell lipotoxicity;
  • glucolipotoxicity;
  • obesity;
  • oxidative stress

Summary

This chapter contains sections titled:

  • Introduction

  • Acute Effect of Glucose and FFA on Insulin Secretion

  • Insulin Secretory Abnormalities in Type 2 Diabetic Patients

  • β-Cell Glucotoxicity

  • β-Cell Lipotoxicity

  • Glucolipotoxicity

  • Oxidative Stress as an Endogenous Toxin

  • Oxidative Stress, β-Cell Glucotoxicity, and Lipotoxicity

  • Conclusion

  • References