Chapter 25. Oxidized Low Density Lipoprotein Cytotoxicity and Vascular Disease

  1. Prof. Peter J. O'Brien2 and
  2. Prof. W. Robert Bruce3,4
  1. Steven P. Gieseg,
  2. Elizabeth Crone and
  3. Zunika Amit

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch25

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Gieseg, S. P., Crone, E. and Amit, Z. (2009) Oxidized Low Density Lipoprotein Cytotoxicity and Vascular Disease, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch25

Editor Information

  1. 2

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 3

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 4

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. University of Canterbury, Free Radical Biochemistry Laboratory, School of Biological Sciences, Private Bag 4800, Christchurch 8140, New Zealand

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100

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Keywords:

  • OxLDL;
  • lipoprotein cytotoxicity;
  • vascular disease;
  • scavenger receptors;
  • atherosclerotic plaque;
  • neopterin;
  • macrophage;
  • heart disease

Summary

This chapter contains sections titled:

  • Introduction to Vascular Disease

  • oxLDL Formation

  • Toxicity of oxLDL

  • Types of oxLDL

  • Cell-Mediated Oxidation and Atherosclerotic Plaques

  • Endogenous Antioxidants

  • Mechanism of oxLDL Cytotoxicity

  • Oxysterol and the Mitochondria

  • Oxysterols and Calcium

  • NADPH Oxidase and Apoptosis versus Necrosis

  • The Future

  • References