Chapter 29. Dopamine Catabolism and Parkinson's Disease: Role of a Reactive Aldehyde Intermediate

  1. Prof. Peter J. O'Brien2 and
  2. Prof. W. Robert Bruce3,4
  1. Jonathan A. Doorn

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch29

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Doorn, J. A. (2009) Dopamine Catabolism and Parkinson's Disease: Role of a Reactive Aldehyde Intermediate, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch29

Editor Information

  1. 2

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 3

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 4

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. The University of Iowa, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, 115 S. Grand Avenue, Iowa City, IA 52242-1112, USA

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100

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Keywords:

  • dopamine catabolism;
  • PD;
  • DOPAL;
  • DOPAC;
  • vesicular monoamine transporter;
  • monoamine oxidase

Summary

This chapter contains sections titled:

  • Dopamine Biosynthesis and Catabolism

  • DOPAL as a Metabolite of DA: Importance to Pharmacology and Toxicology

  • DOPAL Metabolism

  • Mechanisms for Elevation in Levels of DOPAL

  • DOPAL Toxicity

  • DOPAL Reactivity with Proteins

  • Relevance of DOPAL to PD: Summary and “Big Picture”

  • Acknowledgments

  • References