Chapter 3. Endogenous Macromolecule Radicals

  1. Prof. Peter J. O'Brien3 and
  2. Prof. W. Robert Bruce4,5
  1. Arno G. Siraki1 and
  2. Marilyn Ehrenshaft2

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch3

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Siraki, A. G. and Ehrenshaft, M. (2009) Endogenous Macromolecule Radicals, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch3

Editor Information

  1. 3

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 4

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 5

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. 1

    NIEHS-NIH, Laboratory of Pharmacology and Chemistry, 111 Alexander Drive, Research Triangle Park, NC 27709, USA

  2. 2

    National Institute of Environmental Health Sciences, National Institutes of Health, Laboratory of Pharmacology, 111 TW Alexander Dr. RTP, Morrisville, NC 27709, USA

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100



  • superoxide;
  • singlet oxygen;
  • IST;
  • macromolecule free radical;
  • photosensitizers;
  • hydroxyl radical;
  • reactive oxygen species


This chapter contains sections titled:

  • Introduction

  • What is a Free Radical?

  • Free Radicals as Initiators of Macromolecule Damage

  • Macromolecule Radical Formation Induced by Small Molecule Free Radicals

  • Examples and Potential Application of Immuno-Spin Trapping (IST) for the Detection of Macromolecule Radicals

  • Immunological Detection of Oxidized Tryptophan Residues in Proteins

  • References