Chapter 32. Endogenous Toxins Associated with Life Expectancy and Aging

  1. Prof. Peter J. O'Brien2 and
  2. Prof. W. Robert Bruce3,4
  1. Victoria Ayala,
  2. Jordi Boada,
  3. José Serrano,
  4. Manuel Portero-Otín and
  5. Reinald Pamplona

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch32

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Ayala, V., Boada, J., Serrano, J., Portero-Otín, M. and Pamplona, R. (2009) Endogenous Toxins Associated with Life Expectancy and Aging, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch32

Editor Information

  1. 2

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 3

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 4

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. University of Lleida-IRBLLEIDA, Department of Experimental Medicine, c/Montserrat Roig 2, 25008 Lleida, Spain

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100

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Keywords:

  • aging;
  • caloric, methionine and protein restriction;
  • DNA damage;
  • free radicals;
  • evolution;
  • life span;
  • membrane unsaturation;
  • methionine;
  • mitochondria;
  • protein oxidation;
  • reactive oxygen species production

Summary

This chapter contains sections titled:

  • Introduction

  • Metabolism(s)

  • The Rate of Generation of Damage Induced by Mitochondrial Free Radicals and Life Span

  • Structural Components that are Highly Resistant to Oxidative Stress and Life Span

  • Oxidative Stress, Aging, and Dietary Restriction

  • Nutritional Considerations on Methionine: A Public Health Matter

  • Acknowledgments

  • References