Chapter 33. Therapeutic Potential for Decreasing the Endogenous Toxin Homocysteine: Clinical Trials

  1. Prof. Peter J. O'Brien2 and
  2. Prof. W. Robert Bruce3,4
  1. Wolfgang Herrmann and
  2. Rima Obeid

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch33

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Herrmann, W. and Obeid, R. (2009) Therapeutic Potential for Decreasing the Endogenous Toxin Homocysteine: Clinical Trials, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch33

Editor Information

  1. 2

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 3

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 4

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. University Hospital of the Saarland, Department of Clinical Chemistry and Laboratory Medicine, Gebäude 57, 66424 Homburg, Germany

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100

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Keywords:

  • homocysteine;
  • hyperhomocysteinemia;
  • cystathionine;
  • 5-methylTHF;
  • cystathionine-β-synthase;
  • methyl trap;
  • pteroylglutamic acid;
  • folate;
  • vitamin B6;
  • B12

Summary

This chapter contains sections titled:

  • Homocysteine Metabolism

  • Physiological Determinants of Plasma Homocysteine Level

  • Causes of Hyperhomocysteinemia

  • The Role of Vitamin B12 (Cobalamin)

  • Folic Acid, Folate (Vitamin B9)

  • Vitamin B6

  • Homocysteine (Hcy) as an Endogenous Toxin – Human and Experimental Studies

  • References