Chapter 4. Alcohol-Derived Bioadducts

  1. Prof. Peter J. O'Brien3 and
  2. Prof. W. Robert Bruce4,5
  1. Geoffrey M. Thiele1 and
  2. Lynell W. Klassen1,2

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch4

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Thiele, G. M. and Klassen, L. W. (2009) Alcohol-Derived Bioadducts, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch4

Editor Information

  1. 3

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 4

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 5

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. 1

    University of Nebraska Medical Center, Department of Internal Medicine, Section of Rheumatology/Immunology, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA

  2. 2

    Department of Veterans Affairs Omaha VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100



  • reactive metabolite;
  • ethanol metabolite;
  • acetaldehyde adduct;
  • malondialdehyde;
  • Amadori product adduct;
  • MAA adduct


This chapter contains sections titled:

  • Introduction

  • The Generation of Reactive Metabolites

  • Ethanol Metabolites React with Proteins

  • Acetaldehyde Adducts

  • Malondialdehyde

  • Malondialdehyde–Acetaldehyde (MAA) Adducts

  • 4-Hydroxyalkenals

  • Free Radical–Derived Adducts

  • 5-Deoxy-D-xylulose-1-phosphate (DXP)

  • Acetaldehyde–Glucose Amadori Product Adduct

  • Immune Responses to Proteins Modified with Alcohol Metabolites

  • The Role of Alcohol-Derived Bioadducts in Alcohol-Related Tissue Injury

  • Future Directions

  • Acknowledgments

  • References