Chapter 9. Estrogens as Endogenous Toxins

  1. Prof. Peter J. O'Brien2 and
  2. Prof. W. Robert Bruce3,4
  1. Jason Matthews

Published Online: 25 JAN 2010

DOI: 10.1002/9783527628100.ch9

Endogenous Toxins: Targets for Disease Treatment and Prevention

Endogenous Toxins: Targets for Disease Treatment and Prevention

How to Cite

Matthews, J. (2009) Estrogens as Endogenous Toxins, in Endogenous Toxins: Targets for Disease Treatment and Prevention (eds P. J. O'Brien and W. R. Bruce), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628100.ch9

Editor Information

  1. 2

    University of Toronto, Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, Room 1004, College Street 144, Toronto, ON M5S 3M2, Canada

  2. 3

    University of Toronto, Fitz Gerald Building, Room 342, College Street 150, Toronto, ON M5S 3E2, Canada

  3. 4

    University of Toronto, Department of Nutritional Sciences, Faculty of Medicine, Toronto, Ontario M5S 2E3, Canada

Author Information

  1. University of Toronto, Department of Pharmacology and, Toxicology, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M55/A8, Canada

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 OCT 2009

ISBN Information

Print ISBN: 9783527323630

Online ISBN: 9783527628100

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Keywords:

  • estrogen receptor;
  • ER-mediated signaling;
  • estrogen responsive element;
  • AHR;
  • coregulator;
  • ATAC trial;
  • DNA damage;
  • oxidative stress

Summary

This chapter contains sections titled:

  • Introduction

  • Estrogen Synthesis

  • Receptor-Mediated Estrogen Signaling

  • DNA Damage Induced by Estrogen

  • Oxidative Metabolism of Estrogen

  • Role for Estrogen Receptor in ROS Generation

  • Treatment of Estrogen-Dependent Diseases

  • Conclusions

  • References