Chapter 13. Brain Interleukin-1 (IL-1) Mediates Stress-Induced Alterations in HPA Activation, Memory Functioning and Neural Plasticity

  1. Prof. Dr. Hermona Soreq2,
  2. Prof. Dr. Alon Friedman3 and
  3. Prof. Dr. Daniela Kaufer4
  1. Inbal Goshen and
  2. Raz Yirmiya

Published Online: 2 DEC 2009

DOI: 10.1002/9783527628346.ch13

Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses

Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses

How to Cite

Goshen, I. and Yirmiya, R. (2009) Brain Interleukin-1 (IL-1) Mediates Stress-Induced Alterations in HPA Activation, Memory Functioning and Neural Plasticity, in Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses (eds H. Soreq, A. Friedman and D. Kaufer), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628346.ch13

Editor Information

  1. 2

    The Hebrew University of Jerusalem, Department of Biological Chemistry, Safra Campus - Givat Ram, Jerusalem 91904, Israel

  2. 3

    Ben Gurion University of the Negev, Departments of Physiology and Neurosurgery, Zlotowksi Centre for Neuroscience, Beer Sheva 84105, Israel

  3. 4

    University of California, Berkeley, Department of Integrative Biology, 3060 Valley Life Sciences Bldg. 3140, Berkeley, CA 94720-3140, USA

Author Information

  1. The Hebrew University of Jerusalem, Department of Psychology, Mount Scopsu, Jerusalem 91905, Israel

Publication History

  1. Published Online: 2 DEC 2009
  2. Published Print: 11 NOV 2009

ISBN Information

Print ISBN: 9783527323746

Online ISBN: 9783527628346

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Keywords:

  • interleukin-1;
  • glucocorticoids;
  • HPA axis;
  • stress;
  • memory;
  • neural plasticity;
  • neurogenesis;
  • glia;
  • norepinephrine

Summary

This chapter contains sections titled:

  • Introduction

  • The Bi-Directional Interaction Between IL-1 and the HPA Axis

  • Stress-Induced HPA Axis Activation is Regulated by Brain IL-1

  • Stress-Induced Alterations in Memory and Neural Plasticity are Regulated by Brain IL-1

  • Summary

  • References