Chapter 8. Corticotropin-Releasing Factor (CRF) and CRF-Related Peptides – a Linkage Between Stress and Anxiety

  1. Prof. Dr. Hermona Soreq2,
  2. Prof. Dr. Alon Friedman3 and
  3. Prof. Dr. Daniela Kaufer4
  1. Thomas Blank and
  2. Joachim Spiess

Published Online: 2 DEC 2009

DOI: 10.1002/9783527628346.ch8

Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses

Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses

How to Cite

Blank, T. and Spiess, J. (2009) Corticotropin-Releasing Factor (CRF) and CRF-Related Peptides – a Linkage Between Stress and Anxiety, in Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses (eds H. Soreq, A. Friedman and D. Kaufer), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527628346.ch8

Editor Information

  1. 2

    The Hebrew University of Jerusalem, Department of Biological Chemistry, Safra Campus - Givat Ram, Jerusalem 91904, Israel

  2. 3

    Ben Gurion University of the Negev, Departments of Physiology and Neurosurgery, Zlotowksi Centre for Neuroscience, Beer Sheva 84105, Israel

  3. 4

    University of California, Berkeley, Department of Integrative Biology, 3060 Valley Life Sciences Bldg. 3140, Berkeley, CA 94720-3140, USA

Author Information

  1. University of Hawaii, Biosciences Building, John A. Burns School of Medicine, 651 Ilalo Street, Honolulu, HI 96813, USA

Publication History

  1. Published Online: 2 DEC 2009
  2. Published Print: 11 NOV 2009

ISBN Information

Print ISBN: 9783527323746

Online ISBN: 9783527628346

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Keywords:

  • neuropeptide;
  • CRF;
  • corticotropin-releasing factor;
  • urocortin;
  • stress;
  • G protein;
  • second messenger;
  • serotonin

Summary

This chapter contains sections titled:

  • The CRF Family, Its Receptors and Ligands

  • The Role of CRF and CRF-Related Peptides in Neuroendocrine Aspects of Stress

  • The Role of CRF and CRF-Related Peptides in Behavioral Aspects of Stress

  • The Role of CRF and CRF-Related Peptides in Anxiety

  • Crosstalk Between the CRF and Serotonin Systems

  • Future Directions

  • Summary

  • References