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Differential Toxicity Characterization of Green Alternative Chemicals

Part 9. Designing Safer Chemicals

  1. Richard Judson

Published Online: 15 APR 2012

DOI: 10.1002/9783527628698.hgc096

Handbook of Green Chemistry

Handbook of Green Chemistry

How to Cite

Judson, R. 2012. Differential Toxicity Characterization of Green Alternative Chemicals. Handbook of Green Chemistry. 9:2:21–46.

Author Information

  1. U.S. Environmental Protection Agency, National Center for Computational Toxicology, NC, USA

Publication History

  1. Published Online: 15 APR 2012

Abstract

The sections in this article are

  • Introduction
  • Chemical Properties Related to Differential Toxicity
  • Modeling Chemical Clearance – Metabolism and Excretion
  • Predicting Differential Inherent Molecular Toxicity
    • Cell Types/Cell Lines
    • High-Throughput Screening (HTS)
    • High-Content Screening (HCS)
    • Whole-Genome Approaches
  • Integrating In Vitro Data to Model Toxicity Potential
  • Databases Relevant for Toxicity Characterization
  • Example of Differential Toxicity Analysis
  • Conclusion
  • Disclaimer

Keywords:

  • differential toxicity;
  • chemical clearance;
  • chemical design;
  • green alternative chemicals;
  • green chemistry