Chapter 15. Depot-Specific Biology of Adipose Tissues: Links to Fat Distribution and Metabolic Risk

  1. Todd Leff2 and
  2. James G. Granneman3
  1. Mi-Jeong Lee and
  2. Susan K. Fried

Published Online: 16 APR 2010

DOI: 10.1002/9783527629527.ch15

Adipose Tissue in Health and Disease

Adipose Tissue in Health and Disease

How to Cite

Lee, M.-J. and Fried, S. K. (2010) Depot-Specific Biology of Adipose Tissues: Links to Fat Distribution and Metabolic Risk, in Adipose Tissue in Health and Disease (eds T. Leff and J. G. Granneman), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629527.ch15

Editor Information

  1. 2

    Wayne State University School of Medicine, Department of Pathology, 540 E. Canfield, Detroit, MI 48201, USA

  2. 3

    Wayne State University School of Medicine, Center for Integrative Metabolic and Endocrine Research, Department of Psychiatry, 550 E. Canfield, Detroit, MI 48201, USA

Author Information

  1. University of Maryland School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, 660 W. Redwood Street, Baltimore, MD 21201, USA

Publication History

  1. Published Online: 16 APR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527318575

Online ISBN: 9783527629527

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Keywords:

  • adipose tissue;
  • fat distribution;
  • metabolic risk;
  • adipocyte;
  • lipolysis;
  • triglyceride

Summary

This chapter contains sections titled:

  • Introduction

  • Adipose Depots: Definitions

  • Physiological and Anatomical Differences among Depots may Drive Functional Heterogeneity

  • Heterogeneity in Adipocyte Function among Adipose Depots

  • Regional Differences in Adipose Tissue Gene Expression and Protein Production: Relationship to the Metabolic Syndrome

  • Search for Novel Adipokines with Depot-Specific Expression that Link Regional Adiposity to Metabolic Risk

  • Importance of Adipose Tissue Macrophages and other Immunocytes in Regional Adipose Tissue Dysfunction

  • Gene Expression Profiles are Providing New Insights on Regional Adipose Growth and Function

  • Depot Differences in Cell Proliferation and Differentiation Capacity

  • Conclusions and Future Directions

  • References