Chapter 17. Platelets: Their Role in Atherogenesis and Thrombosis in Coronary Artery Disease

  1. Dr. Sarah Jane George and
  2. Dr. Jason Johnson
  1. Matthew T. Harper,
  2. Lucy MacCarthy-Morrogh,
  3. Matthew L. Jones,
  4. Olga Konopatskaya and
  5. Alastair W. Poole

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629589.ch17

Atherosclerosis: Molecular and Cellular Mechanisms

Atherosclerosis: Molecular and Cellular Mechanisms

How to Cite

Harper, M. T., MacCarthy-Morrogh, L., Jones, M. L., Konopatskaya, O. and Poole, A. W. (2010) Platelets: Their Role in Atherogenesis and Thrombosis in Coronary Artery Disease, in Atherosclerosis: Molecular and Cellular Mechanisms (eds S. J. George and J. Johnson), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629589.ch17

Editor Information

  1. Bristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, United Kingdom

Author Information

  1. University of Bristol, Department of Physiology and Pharmacology, University Walk, Bristol BS8 1TD, UK

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 17 FEB 2010

ISBN Information

Print ISBN: 9783527324484

Online ISBN: 9783527629589

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Keywords:

  • dense granules;
  • inside-out activation;
  • lysosomes;
  • platelet adhesion;
  • prostacyclin;
  • tethering and rolling;
  • tissue factor;
  • von Willebrand factor;
  • α-granules

Summary

This chapter contains sections titled:

  • Introduction

  • Platelets

  • Role of Platelets in Atheroprogression

  • Role of Platelets in Atherothrombosis

  • Mechanisms of Platelet Granule Secretion

  • Conclusion

  • References