Chapter 10. The Development of an Environmentally Sustainable Process for Radafaxine

  1. Dr. Peter J. Dunn2,3,
  2. Dr. Andrew S. Wells4 and
  3. Dr. Michael T. Williams5
  1. Trevor Grinter

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629688.ch10

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

How to Cite

Grinter, T. (2010) The Development of an Environmentally Sustainable Process for Radafaxine, in Green Chemistry in the Pharmaceutical Industry (eds P. J. Dunn, A. S. Wells and M. T. Williams), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629688.ch10

Editor Information

  1. 2

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  2. 3

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  3. 4

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  4. 5

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Author Information

  1. Roystons, New Road, Rotherfield, East Sussex, TN6 3JS, UK

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527324187

Online ISBN: 9783527629688

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Keywords:

  • bupropion;
  • radafaxine;
  • dynamic kinetic resolution;
  • multicolumn chromatography;
  • life cycle metrics

Summary

This chapter contains sections titled:

  • Introduction

  • Chemistry Process and the Dynamic Kinetic Resolution (DKR)

  • Multicolumn Chromatography – Development of Route 4

  • Environmental Assessment

  • Summary

  • Acknowledgments

  • References