Chapter 11. Continuous Processing in the Pharmaceutical Industry

  1. Dr. Peter J. Dunn3,4,
  2. Dr. Andrew S. Wells5 and
  3. Dr. Michael T. Williams6
  1. Lee Proctor1,
  2. Dr. Peter J. Dunn3,4,
  3. Joel M. Hawkins2,
  4. Dr. Andrew S. Wells5 and
  5. Dr. Michael T. Williams6

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629688.ch11

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

How to Cite

Proctor, L., Dunn, P. J., Hawkins, J. M., Wells, A. S. and Williams, M. T. (2010) Continuous Processing in the Pharmaceutical Industry, in Green Chemistry in the Pharmaceutical Industry (eds P. J. Dunn, A. S. Wells and M. T. Williams), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629688.ch11

Editor Information

  1. 3

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  2. 4

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  3. 5

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  4. 6

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Author Information

  1. 1

    Phoenix Chemicals Ltd., Croft Business Park, 34 Thursby Road, Bromborough, Wirral CH62 3PW, UK

  2. 2

    Pfizer Global R&D, Chemical R&D Department, MS 4073, Eastern Point Road, Groton, CT 06340, USA

  3. 3

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  4. 4

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  5. 5

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  6. 6

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527324187

Online ISBN: 9783527629688

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Keywords:

  • continuous processing;
  • process analytical technology;
  • process control system;
  • atorvastatin;
  • variable residence time reactor;
  • celecoxib;
  • diazomethane;
  • bromonitromethane

Summary

This chapter contains sections titled:

  • Introduction

  • Continuous Production of a Key Intermediate for Atorvastatin

  • Continuous Process to Prepare Celecoxib

  • Continuous Oxidation of Alcohols to Aldehydes

  • Continuous Production of Bromonitromethane

  • Continuous Production and Use of Diazomethane

  • A Snapshot of Some Further Continuous Processes Used in the Preparation of Pharmaceutical Agents

  • Conclusions

  • Acknowledgments

  • References