Chapter 12. Preparative and Industrial Scale Chromatography: Green and Integrated Processes

  1. Dr. Peter J. Dunn5,6,
  2. Dr. Andrew S. Wells7 and
  3. Dr. Michael T. Williams8
  1. Eric Lang1,
  2. Eric Valéry2,
  3. Olivier Ludemann-Hombourger3,
  4. Wieslaw Majewski4 and
  5. Jean Bléhaut1

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629688.ch12

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

How to Cite

Lang, E., Valéry, E., Ludemann-Hombourger, O., Majewski, W. and Bléhaut, J. (2010) Preparative and Industrial Scale Chromatography: Green and Integrated Processes, in Green Chemistry in the Pharmaceutical Industry (eds P. J. Dunn, A. S. Wells and M. T. Williams), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629688.ch12

Editor Information

  1. 5

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  2. 6

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  3. 7

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  4. 8

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Author Information

  1. 1

    Groupe Novasep SAS, 82, Boulevard de la Moselle-BP50, Pompey-54340, France

  2. 2

    Novasep Process SAS 81, Boulevard de la Moselle 54340 Pompey, France

  3. 3

    Lonza Braine SA, Chausée de Tubize 297, Braine-l'Alleud-1420, Belgium

  4. 4

    Novasep Process SAS, 81, Boulevard de la Moselle-BP50, Pompey-54340, France

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527324187

Online ISBN: 9783527629688

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Keywords:

  • preparative chromatography;
  • industrial scale chromatography;
  • continuous chromatography;
  • supercritical fluid chromatography;
  • SMB;
  • SFC;
  • HPLC;
  • solvent recycling

Summary

This chapter contains sections titled:

  • Introduction

  • Basic Principles of Chromatography

  • Process Optimization to Reduce Eluent Consumption

  • Use of a Green Solvent: Supercritical Carbon Dioxide

  • Solvent Recycling Technologies

  • Application Examples

  • Conclusion: An Environmentally Friendly Solution for Each Separation

  • Acknowledgment

  • References