Chapter 13. Dynamic Resolution of Chiral Amine Pharmaceuticals: Turning Waste Isomers into Useful Product

  1. Dr. Peter J. Dunn3,4,
  2. Dr. Andrew S. Wells5 and
  3. Dr. Michael T. Williams6
  1. John Blacker1 and
  2. Catherine E. Headley2

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629688.ch13

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

How to Cite

Blacker, J. and Headley, C. E. (2010) Dynamic Resolution of Chiral Amine Pharmaceuticals: Turning Waste Isomers into Useful Product, in Green Chemistry in the Pharmaceutical Industry (eds P. J. Dunn, A. S. Wells and M. T. Williams), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629688.ch13

Editor Information

  1. 3

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  2. 4

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  3. 5

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  4. 6

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Author Information

  1. 1

    University of Leeds, Institute of Process R + D, School of Chemistry, Woodhouse Lane, Leeds, LS2 9JT, UK

  2. 2

    University of Manchester, Business Relations Team, Oxford Road, Manchester, MI3 9PL, UK

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527324187

Online ISBN: 9783527629688

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Keywords:

  • dynamic kinetic resolution;
  • chiral amine pharmaceuticals;
  • enzyme-based resolution;
  • simulated moving bed;
  • diastereomeric salt crystallization;
  • dynamic thermodynamic resolution;
  • sertraline

Summary

This chapter contains sections titled:

  • Background

  • Integration of Chiral Amine Resolution and Racemization

  • Case Studies

  • Conclusions

  • Acknowledgments

  • References