Chapter 14. Green Technologies in the Generic Pharmaceutical Industry

  1. Dr. Peter J. Dunn3,4,
  2. Dr. Andrew S. Wells5 and
  3. Dr. Michael T. Williams6
  1. Apurba Bhattacharya1 and
  2. Rakeshwar Bandichhor2

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629688.ch14

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

How to Cite

Bhattacharya, A. and Bandichhor, R. (2010) Green Technologies in the Generic Pharmaceutical Industry, in Green Chemistry in the Pharmaceutical Industry (eds P. J. Dunn, A. S. Wells and M. T. Williams), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629688.ch14

Editor Information

  1. 3

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  2. 4

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  3. 5

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  4. 6

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Author Information

  1. 1

    Texas A&M University, Department of Chemistry, 920 W. Santa Gertrudes, Kingsville, TX 78363, USA

  2. 2

    Center of Excellence, Research & Development Integrated Product Development, Dr. Reddy's Laboratories Ltd., Survey Nos. 42, 45, 46 & 54, Bachupally, Qutubullapur, Ranga Reddy Dist 500072, Andhra Pradesh, India

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527324187

Online ISBN: 9783527629688

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Keywords:

  • generic pharmaceuticals;
  • atom economy;
  • amidation;
  • N-heterocyclic carbene catalyst;
  • galanthamine;
  • solefinacin;
  • levetiracatam;
  • finasteride;
  • zafirlukast;
  • rabeprazole

Summary

This chapter contains sections titled:

  • Introduction

  • ‘Waste’: Definition and Remedy

  • Amidation

  • Synthesis of Galanthamine

  • Synthesis of Solefinacin

  • Synthesis of Levetiracetam

  • Synthesis of a Finasteride Intermediate

  • Bromination

  • Sulfoxidation in the Synthesis of Rabeprazole

  • Conclusions

  • Acknowledgments

  • References