Chapter 6. The Development of Short, Efficient, Economic, and Sustainable Chemoenzymatic Processes for Statin Side Chains

  1. Dr. Peter J. Dunn4,5,
  2. Dr. Andrew S. Wells6 and
  3. Dr. Michael T. Williams7
  1. Martin Schürmann1,
  2. Michael Wolberg2,
  3. Sven Panke3 and
  4. Hans Kierkels1

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629688.ch6

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

How to Cite

Schürmann, M., Wolberg, M., Panke, S. and Kierkels, H. (2010) The Development of Short, Efficient, Economic, and Sustainable Chemoenzymatic Processes for Statin Side Chains, in Green Chemistry in the Pharmaceutical Industry (eds P. J. Dunn, A. S. Wells and M. T. Williams), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629688.ch6

Editor Information

  1. 4

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  2. 5

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  3. 6

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  4. 7

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Author Information

  1. 1

    DSM Pharma Chemicals, Department: DSM Innovative, Synthesis BV, P.O. Box 18, 6160 MD Geleen, The Netherlands

  2. 2

    DSM Pharma Chemicals-ResCom, DPC Regensburg GmbH, Donaustaufer Str. 378, 93055 Regensburg, Germany

  3. 3

    ETH Zürich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527324187

Online ISBN: 9783527629688

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Keywords:

  • aldolase;
  • chemoenzymatic processes;
  • biocatalysis;
  • statin side chains

Summary

This chapter contains sections titled:

  • Introduction: Biocatalysis

  • The Relevance of Statins

  • Biocatalytic Routes to Statin Side Chains

  • 2-Deoxy-d-Ribose 5-Phosphate Aldolase (DERA)-Based Routes to Statin Intermediates

  • Conclusions

  • Acknowledgments

  • References