Chapter 7. The Taxol® Story – Development of a Green Synthesis via Plant Cell Fermentation

  1. Dr. Peter J. Dunn2,3,
  2. Dr. Andrew S. Wells4 and
  3. Dr. Michael T. Williams5
  1. Pia G. Mountford

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629688.ch7

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

How to Cite

Mountford, P. G. (2010) The Taxol® Story – Development of a Green Synthesis via Plant Cell Fermentation, in Green Chemistry in the Pharmaceutical Industry (eds P. J. Dunn, A. S. Wells and M. T. Williams), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629688.ch7

Editor Information

  1. 2

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  2. 3

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  3. 4

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  4. 5

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Author Information

  1. Bristol Myers Squibb, 777 Scudders Mill Road, Plainsboro, NJ 08536, USA

  1. At the outset, it is pivotal to note that, as the author of this chapter, I can claim absolutely none of the credit for the dedication and commitment of the scientists, clinicians and hosts of other people who were the actual inventors and developers of Taxol® through its various incarnations. I will simply try to tell the story.

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527324187

Online ISBN: 9783527629688

SEARCH

Keywords:

  • Taxol®;
  • plant cell fermentation;
  • paclitaxel;
  • Pacific yew tree

Summary

This chapter contains sections titled:

  • Introduction

  • Discovery and Early Development

  • From Extraction of Taxol® from Pacific Yew Tree Bark to Semi-Synthetic Taxol®

  • Taxol® from Plant Cell Fermentation

  • Comparison of Semi-Synthetic versus PCF Taxol® Processes: The Environmental Impact

  • Comparison of Semi-Synthetic versus PCF Taxol®: Green Chemistry Principles

  • Final Words

  • Acknowledgments

  • References